Cancer is considered to be a global health problem. Moreover, the increasing resistance to the established anticancer drugs is of grave concern. Deregulation of the kinase activity has emerged as a major mechanism by which cancer cells evade normal physiological constraints on growth and survival. Such aberrant functions of the kinases in a cancer cell have highlighted them as one of the most successful families of drug targets. Our research group at IITGN focusses on the chemical biology of cancer-related protein kinases involved in the DNA damage response pathways which can be used as targets for the anti-cancer therapy. We use small molecule inhibitors approach to study these proteins so as to develop new age cancer therapeutics.
Our Research Approach
Signaling pathways that we focus on