Evolution of mobile genetic elements/ transposons: mechanisms of transposition and control, modifications of function in transposase homologs
Biochemical/biophysical/structural characterization of nucleotide-binding & nucleic acid binding proteins
Genomic and proteomic analysis of transposases and transposase homologs.
Assistant Professor, Indian Institute of Technology Gandhinagar (Jan 2014 to present)
Post Doctoral Researcher, University of California, Berkeley (Dec 2007 - Dec 2013)
Selected Recent Publications
Majumdar S., Singh A. and Rio D.C. The human THAP9 gene encodes an active P element DNA transposase. Science . 2013 Jan 25;339(6118):446-8.
Majumdar S. and Rio D.C.Specificity of DNA-Protein Recognition by THAP9 Family DNA Binding Domains. Submitted.
Majumdar S. , Libeu S. and Rio D.C.Molecular evolution of novel hyperactive P-element transposase mutants . Submitted.
Majumdar S., Ramachandran S., Cerione R.A. New insights into the role of conserved, essential residues in the GTP -binding/GTP hydrolytic reaction of large G proteins. J. Biol. Chem. 2006 Apr 7; 281(14): 9219-9226. Epub 2006 Feb 9.
Majumdar S. , Ramachandran S., Cerione R.A. Perturbing the linker regions of the alpha- subunit of transducin: a new class of constitutively active GTP- binding proteins. J. Biol. Chem. 2004 Sep 17; 279(38): 40137 -40145. Epub 2004 Jul 22.