Protein Aggregation Pathways and Their Role in Neurodegenerative Disorders
Peptides as Therapeutics in Alzheimer’s Disease.
Solid Phase Synethesis of Aggregation Prone Difficult Peptides.
Novel Antimicrobial Peptidomimetic Scaffolds.
Assistant Professor, Indian Institute of Technology Gandhinagar (July 2012 to present)
Post Doctoral Fellow, Department of Chemical and Biomolecular Engineering, University of Delaware (Aug 2010 - June 2012)
Post Doctoral Researcher, Department of Chemistry, Temple University (Sept 2009-July 2010)
Selected Recent Publications
Ralhan, K.; Guru Krishna Kumar, V.; Gupta. S. “Piperazine and DBU: a safer alternative for rapid and efficient fmoc deprotection in solid phase peptide synthesis.” RSC Advances, 2015, 5, 104417-104425. DOI: 10.1039/C5RA23441G.
Morozova, O. A.*; Gupta, S.*; Colby, D. W. “Prefibrillar Huntington oligomers isolated from HD brain potentially seed amyloid formation” FEBS letters, 589(15):1897-903, 2015. doi: 10.1016/j.febslet.2015.05. * Equal contribution.
Gupta, S.; Jie, S.; Colby, D. W. “Protein misfolding detected early in the pathogenesis of a transgenic mouse model of Huntington's disease using an amyloid seeding assay.” J. Biol. Chem. 2012, 287, 9982-9989.
Gupta, S.; Schafmeister, C. E. “Synthesis of a Carboxylate Functionalized Bis-Amino Acid Monomer.” J. Org. Chem. 2009, 74, 3652-3658.
Schafmeister, C. E., Brown, Z. Z., Gupta, S. “Shape programmable Macromolecules.” Acc. Chem. Res. 2008, 41, 1387-1398.